I really want that allegation not to be true. I drink a lot of sucralose: it's my favorite sweetener. It's existed for like 50 years and has been one of the most tested artificial sweeteners. It's always been concluded as safe and non-toxic.
Sweeteners work in a couple ways. The first is that it is a sugar molecule that can't be split into glucose, and thus can't be absorbed through the gut. Since the sweetener is not absorbed by the gut it exits in the usual way.
Some of these sugar molecules are digestible by gut microbes, which leads to selection for gut flora that can gain energy from these indigestible sugars. This is what happens to people with lactose intolerance.
The second type are absorbed through the gut and then immediately eliminated by the kidneys. Sugar alcohols act in this way.
Changing the micro-biome has all kinds of complex effects. It isn't straightforward what the interactions between the micro-biome and the human immune system.
I know the frustration, friendo, I still consume a lot of artificial sweeteners, but recently I discovered that sucralose may contribute to a permeable intestine/leaky gut.
At high concentrations, aspartame and saccharin induce apoptosis and cell death, while at low concentrations, sucralose and aspartame increased epithelial barrier permeability and down-regulated claudin 3 at the cell surface.
I really want that allegation not to be true. I drink a lot of sucralose: it's my favorite sweetener. It's existed for like 50 years and has been one of the most tested artificial sweeteners. It's always been concluded as safe and non-toxic.
Sweeteners work in a couple ways. The first is that it is a sugar molecule that can't be split into glucose, and thus can't be absorbed through the gut. Since the sweetener is not absorbed by the gut it exits in the usual way.
Some of these sugar molecules are digestible by gut microbes, which leads to selection for gut flora that can gain energy from these indigestible sugars. This is what happens to people with lactose intolerance.
The second type are absorbed through the gut and then immediately eliminated by the kidneys. Sugar alcohols act in this way.
Changing the micro-biome has all kinds of complex effects. It isn't straightforward what the interactions between the micro-biome and the human immune system.
At least you're too old for childhood asthma
He's not too old for other nasty diseases caused by inflammation though.
I know the frustration, friendo, I still consume a lot of artificial sweeteners, but recently I discovered that sucralose may contribute to a permeable intestine/leaky gut.
https://pmc.ncbi.nlm.nih.gov/articles/PMC7353258/