I know the frustration, friendo, I still consume a lot of artificial sweeteners, but recently I discovered that sucralose may contribute to a permeable intestine/leaky gut.
At high concentrations, aspartame and saccharin induce apoptosis and cell death, while at low concentrations, sucralose and aspartame increased epithelial barrier permeability and down-regulated claudin 3 at the cell surface.
I know the frustration, friendo, I still consume a lot of artificial sweeteners, but recently I discovered that sucralose may contribute to a permeable intestine/leaky gut.
https://pmc.ncbi.nlm.nih.gov/articles/PMC7353258/