Ivermectin tablets are approved by the FDA to treat people with intestinal strongyloidiasis and onchocerciasis, two conditions caused by parasitic worms. In addition, some topical (on the skin) forms of ivermectin are approved to treat external parasites like head lice and for skin conditions such as rosacea.
Here is something I found with a REALLY quick search. Interesting to see the language used in 2012:
Results: Ivermectin, a broadly used anti-helminthic drug, proved to be a highly potent inhibitor of YFV replication (EC₅₀ values in the sub-nanomolar range). Moreover, ivermectin inhibited, although less efficiently, the replication of several other flaviviruses, i.e. dengue fever, Japanese encephalitis and tick-borne encephalitis viruses. Ivermectin exerts its effect at a timepoint that coincides with the onset of intracellular viral RNA synthesis, as expected for a molecule that specifically targets the viral helicase.
Conclusions: The well-tolerated drug ivermectin may hold great potential for treatment of YFV infections. Furthermore, structure-based optimization may result in analogues exerting potent activity against flaviviruses other than YFV.
"Ivermectin, ‘Wonder drug’ from Japan: the human use perspective" Feb 2011
"Ivermectin has continually proved to be astonishingly safe for human use. Indeed, it is such a safe drug, with minimal side effects, that it can be administered by non-medical staff and even illiterate individuals in remote rural communities, provided that they have had some very basic, appropriate training. This fact has helped contribute to the unsurpassed beneficial impact that the drug has had on human health and welfare around the globe, especially with regard to the campaign to fight Onchocerciasis.57)"
Seems like there has been a huge shift in the opinion of our scientific overlords regarding the safety of Ivermectin in humans.
We need some hard data on places that used it during the pandemic.
There are few drugs that can seriously lay claim to the title of ‘Wonder drug’, penicillin and aspirin being two that have perhaps had greatest beneficial impact on the health and wellbeing of Mankind. But ivermectin can also be considered alongside those worthy contenders, based on its versatility, safety and the beneficial impact that it has had, and continues to have, worldwide—especially on hundreds of millions of the world’s poorest people.
Safety, tolerability, and pharmacokinetics of escalating high doses of ivermectin in healthy adult subjects (From October 2002)
Abstract
Safety and pharmacokinetics (PK) of the antiparasitic drug ivermectin, administered in higher and/or more frequent doses than currently approved for human use, were evaluated in a double-blind, placebo-controlled, dose escalation study. Subjects (n = 68) were assigned to one of four panels (3:1, ivermectin/placebo): 30 or 60 mg (three times a week) or 90 or 120 mg (single dose). The 30 mg panel (range: 34 7-594 microg/kg) also received a single dose with food after a 1-week washout. Safety assessments addressed both known ivermectin CNS effects and general toxicity. The primary safety endpoint was mydriasis, accurately quantitated by pupillometry. Ivermectin was generally well tolerated, with no indication of associated CNS toxicity for doses up to 10 times the highest FDA-approved dose of 200 microg/kg. All dose regimens had a mydriatic effect similar to placebo. Adverse experiences were similar between ivermectin and placebo and did not increase with dose. Following single doses of 30 to 120 mg, AUC and Cmax were generally dose proportional, with t(max) approximately 4 hours and t1/2 approximately 18 hours. The geometric mean AUC of 30 mg ivermectin was 2.6 times higher when administered with food. Geometric mean AUC ratios (day 7/day 1) were 1.24 and 1.40 for the 30 and 60 mg doses, respectively, indicating that the accumulation of ivermectin given every fourth day is minimal. This study demonstrated that ivermectin is generally well tolerated at these higher doses and more frequent regimens.
It's blown out of proportion. Some poison control centers (notably Mississippi) reported that "somebody did something", but we really have no idea if it's anything worthy of concern. Probably some moron ate the whole tube. I blame stupid FDA regulations for people having to use horse paste.
Can't remember since it's been a while, but pretty sure that incident was highly suspect of being an attempted murder while trying to shift the blame to Trump.
Yep, she and her husband had a history of documented conflict, she had repeatedly donated to Democrats, and then soon after her husband died she was talking to media saying they ate it because it said "chloroquine" on the fish tank cleaner and Trump had said that would work.
Maybe if the FDA, CDC, NIH, and APhA weren't submarining efforts into this medication people wouldn't be forced to find alternative means.
It's interesting that none of these interventions are ever made for opiates. In fact, the left advocates for junkies to get their fix from taxpayer-funded distribution sites along with needle swaps. Yet for something that is proven not only as a cure but a prophylaxis, that must not be allowed.
The horse paste comes in an application tube. The tube has a plunger segmented in 250lbs increments each divided by 5 notches in 50lbs increments. If you can add and subtract you can safely dose yourself. No conversions necessary.
I think the claim of overdoses, while possible, are being blown way out of proportion. Remember, if ivermectin is proven to be effective then the EUA's will be revoked. That's why they don't want people using it, but that cat is already out of the bag.
They have been denying Ivermectin because the law does not allow them to use emergency regulations to administer untested vaccines if alternative treatments exist.
Here's the FDA's own website: https://archive.is/DBnG5
Which proves what we already know. They are not acting stupid or ignorantly, they are evil and know what they are doing.
The sooner people recognize that, the sooner they can stop dancing around solutions to a very obvious and unchanging problem.
bubububut the vacs is officiall approved now!!!! (so you retards took an experiment?? LMFAO gay niggas)
Ivermectin safe enough to use for head lice, too risky to use if someone's dying of a respiratory infection. Clown...Fucking...World...
https://archive.ph/WwjpO
Here is something I found with a REALLY quick search. Interesting to see the language used in 2012:
Results: Ivermectin, a broadly used anti-helminthic drug, proved to be a highly potent inhibitor of YFV replication (EC₅₀ values in the sub-nanomolar range). Moreover, ivermectin inhibited, although less efficiently, the replication of several other flaviviruses, i.e. dengue fever, Japanese encephalitis and tick-borne encephalitis viruses. Ivermectin exerts its effect at a timepoint that coincides with the onset of intracellular viral RNA synthesis, as expected for a molecule that specifically targets the viral helicase.
Conclusions: The well-tolerated drug ivermectin may hold great potential for treatment of YFV infections. Furthermore, structure-based optimization may result in analogues exerting potent activity against flaviviruses other than YFV.
Remember to archive it before they take the study down.
Thanks for the reminder!
better yet grab the pdf so you can share it around after.
When did they start using colloquialisms? The agency is a joke.
Y'all can't behave.
Another one:
https://archive.ph/oNsC8
"Ivermectin, ‘Wonder drug’ from Japan: the human use perspective" Feb 2011
"Ivermectin has continually proved to be astonishingly safe for human use. Indeed, it is such a safe drug, with minimal side effects, that it can be administered by non-medical staff and even illiterate individuals in remote rural communities, provided that they have had some very basic, appropriate training. This fact has helped contribute to the unsurpassed beneficial impact that the drug has had on human health and welfare around the globe, especially with regard to the campaign to fight Onchocerciasis.57)"
Seems like there has been a huge shift in the opinion of our scientific overlords regarding the safety of Ivermectin in humans.
We need some hard data on places that used it during the pandemic.
Brilliant find. I liked this paragraph.
https://archive.ph/3gAcM
Safety, tolerability, and pharmacokinetics of escalating high doses of ivermectin in healthy adult subjects (From October 2002)
Abstract Safety and pharmacokinetics (PK) of the antiparasitic drug ivermectin, administered in higher and/or more frequent doses than currently approved for human use, were evaluated in a double-blind, placebo-controlled, dose escalation study. Subjects (n = 68) were assigned to one of four panels (3:1, ivermectin/placebo): 30 or 60 mg (three times a week) or 90 or 120 mg (single dose). The 30 mg panel (range: 34 7-594 microg/kg) also received a single dose with food after a 1-week washout. Safety assessments addressed both known ivermectin CNS effects and general toxicity. The primary safety endpoint was mydriasis, accurately quantitated by pupillometry. Ivermectin was generally well tolerated, with no indication of associated CNS toxicity for doses up to 10 times the highest FDA-approved dose of 200 microg/kg. All dose regimens had a mydriatic effect similar to placebo. Adverse experiences were similar between ivermectin and placebo and did not increase with dose. Following single doses of 30 to 120 mg, AUC and Cmax were generally dose proportional, with t(max) approximately 4 hours and t1/2 approximately 18 hours. The geometric mean AUC of 30 mg ivermectin was 2.6 times higher when administered with food. Geometric mean AUC ratios (day 7/day 1) were 1.24 and 1.40 for the 30 and 60 mg doses, respectively, indicating that the accumulation of ivermectin given every fourth day is minimal. This study demonstrated that ivermectin is generally well tolerated at these higher doses and more frequent regimens.
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It's blown out of proportion. Some poison control centers (notably Mississippi) reported that "somebody did something", but we really have no idea if it's anything worthy of concern. Probably some moron ate the whole tube. I blame stupid FDA regulations for people having to use horse paste.
You mean like last year where that woman probably killed her husband with fishtank cleaner and then went on the media and blamed Trump?
Can't remember since it's been a while, but pretty sure that incident was highly suspect of being an attempted murder while trying to shift the blame to Trump.
Yep, she and her husband had a history of documented conflict, she had repeatedly donated to Democrats, and then soon after her husband died she was talking to media saying they ate it because it said "chloroquine" on the fish tank cleaner and Trump had said that would work.
Didn't they find exactly zero fish tank cleaner in her system?
I don't remember that detail, but I'd believe it.
It's the same exact thing as that "fish tank cleaner" bullshit they were going on about with HCQ.
Anything to avoid having people take cheap and effective alternatives to their shitty non-vaccines.
Maybe if the FDA, CDC, NIH, and APhA weren't submarining efforts into this medication people wouldn't be forced to find alternative means.
It's interesting that none of these interventions are ever made for opiates. In fact, the left advocates for junkies to get their fix from taxpayer-funded distribution sites along with needle swaps. Yet for something that is proven not only as a cure but a prophylaxis, that must not be allowed.
Yes, it tells you how much to take per bodyweight. It's no different than some asshole taking 30 ibuprofen even though it says to take 2.
The horse paste comes in an application tube. The tube has a plunger segmented in 250lbs increments each divided by 5 notches in 50lbs increments. If you can add and subtract you can safely dose yourself. No conversions necessary.
I think the claim of overdoses, while possible, are being blown way out of proportion. Remember, if ivermectin is proven to be effective then the EUA's will be revoked. That's why they don't want people using it, but that cat is already out of the bag.
They have been denying Ivermectin because the law does not allow them to use emergency regulations to administer untested vaccines if alternative treatments exist.
If the FDA ever admits ivermectic in a treatment for covid then the emergency authorization for mRNA gene therapies will be revoked.
I give it two, maybe three years before the FDA even begins looking at claims that ivermectin treats covid.