The only legit one I've seen was in Zombieland Saga. The blue haired kid that died of a heart attack, because he freaked out about going into puberty and growing a beard. lol

But usually it's either localizer freaks (Mashle season 2 is unwatchable) or the stupid fandom (recently started reading some isekai slop that featured a boy being forced to crossdess and the comment section is full of people sqeeing over their "trans queen")