The problem with prion diseases is that they are transmissible through various types of animals.

The big BSE (Mad Cow) scare in Great Britain was caused, IIRC, because farmers destroyed sick sheep, and rather than disposing of the bodies, they processed them into cattle feed, which infected the cows.

Prions are very difficult to destroy, even with high temperatures, so don't feed potentially sick animals (or people) to your pigs if you intend to eat those pigs later.

Or, even better, use the blood and bone meal as fertilizer.

No, don't eat the person

Don't eat apex organisms in general.

Those food charts which have a large predator at the top? That's also the direction toxins, parasites, and other contaminants flow, resulting in things like DDT affecting egg development in birds. This is why hunters who shoot then consume bear meat can contract Trichinella which is commonly found in uncooked pork but because wild boar will be consumed by bears [which then aren't consumed by anything else because apex predator] those parasites accumulate and "spoil" the meat for anything that then, somehow, comes along and consumes the apex.

Similarly many large apex sharks like the Great White tastes absolutely horrible for reasons of anatomy. They have no swim bladder so need to do other things to prevent them from sinking. Sharks use Tri-Methyl-Amine-Oxide [TMAO] and urea to provide buoyancy and the urea especially makes shark meat taste foul. This is possibly one of the reasons Nordic countries pickle shark meat for so long as it's just not palatable when raw or even quickly cooked.

Humans greatly disturb this cycle of apex accumulation though as we developed tools like weapons to bypass a lot of features in the wild so apex predators are something we as a species can still kill then consume.

Many parasites in these cycles also affect host behaviour or appearance to the point it increases likelihood of consequential death by another host.

1. Polymorphus minutus affects both the behaviour and appearance of freshwater shrimp, Gammarus pulex, so that predatory fish and birds have an easier time catching the shrimp. The behavioural changes are increase time spent near the water surface and the appearance changes to include extremely conspicuous orange dots which is the parasite aggregating to form visible signs for predators to find.

2. Somewhat of a meme example by Hypnotoad is a real thing. It's just the result of parasitic worms blinding toads by occupying the inside of the eye. There are snails/slugs which have similar parasites in their eyestalks. If prey can't see a predator coming that's an easy meal for the predator.

3. The Lancet fluke, Dicrocoelium dendriticum, infects ants, cows, and snails. Cows shit out eggs, snails consume the shit and eggs then partition the parasites in cysts which are passed out in their mucus, ants consume the mucus for moisture and pick up the cysts which emerge in the ants, mind control them to climb grass blades at night [because day time would desiccate and kill both the ant and parasite], and cows then eat the grass and infected ant. Cows are the definitive host which is the one the parasite reproduces in because a) large, warm blooded mammal = free heat source + lots of space, b) increase dispersal area [although birds are even better since those can fly], and c) very resilient host compared to other options to less likely to die and take the parasites with it. All throughout that cycle the parasite involved doesn't "want" the cow to die as it's that important to its own reproduction and even when you have thousands of parasites in a cow like this they aren't going to do enough damage to it for it to matter. Unlike with the ants.