The past few years, I've been donating to a charity that focuses on helping children who have cancer. I did a fair amount of research and feel confident that they use the funds better than most charities.
I also look around for local charities and donate a bit for things like sports equipment and whatnot.
Just thought I'd see what others are doing and maybe change it up this year.
Use charitynavigator.org to see ratings based on how charities spend their money.
Guidestar is good too. Assuming they aren't jewed.