I just watched it. Is it woke, I don't recall seeing a black person in it. So the casting represents the population of Europe at the time. Is it gay or feminist, not really. Victor has weird attachment issues with his mom and the creature, but nothing overtly gay or feminist in it. I didn't see anything really pushing a modern progressive message.
It has Del Toro's gothic aesthetic. There were shots that showed deep green lighting I think are in every Del Toro movie. It has a lot of gore. People are treated like blood bags throughout the movie.
I think it's a good movie with some pacing issues. I think some parts are too slow and other parts happen quickly with little build-up. My biggest gripe about the movie is the Elizabeth character. She really doesn't add much and her instant attraction and love for the creature is weird. And personally I don't understand the fascination with Mia Goth, I think she's odd looking and a fair actress at best.
TL:DR - Frankenstein is a decent adaptation with gore and no overt modern progressivism.
I get the appeal entirely and even if not reanimating a corpse it's message has universal appeal and moral implications.
Like OP said it's about playing God and toying with forces beyond not necessarily our intelligence, but beyond our ethical comprehension.
In the movie Frankenstein spends so much time trying to bring something to life he never once for a second thought about what he'd do once it was alive. The thing was like a baby and all it wanted was a parent. It was actually sad. I thought of my own kids and when they want to play and I'm dismissive because of work or stress or whatever. It was super relatable movie and I think the original story is too. What about nuclear bombs? Vaccines? Abortion? IVF? Cloning? All have moral implications that no one bothers to think about until after.