no known negative side effects in humans

Food additives have a really weird regulatory framework that effectively seems to operate under the presumption of safety, so if there's chatter that studies are starting to show something might be amiss with a given additive, manufacturers can proactively swap in new things that have no record of causing issues (because they have no record at all). This, along with cost savings, is why our favorite processed snacks don't hit like they used too: they've all got a treadmill of shifting ingredients and aren't same as we remember. The Twinkie of Theseus, if you will.