I think its possible but only in certain subsets of people that are susceptible to it. The same way now that things like hypnotism (the self done version), ASMR, and other various forms of delusional thought only effect certain people right now. The kind of people who can be lulled into dissociative states through certain stimuli already.

I don't think it'll have much effect on greater reality, because we already have people that delusional making up the majority of the Left, who cannot tell reality from the media itself.

So instead it'll just be gooners getting entirely too gross and sad loners getting way to into their waifu simulation.