I've only ever had issues with Bluetooth. As others said I use a wired connection (I even have a four-port USB on an extended cable, so it's like those old-school Mutli-Tap adapters for the Genesis/PSX), plug in all sorts of controllers; Switch, PS4, Xbox, and third-party controllers. Never had any issues except for using Nucleus for split-screen play on games with non-native split-screen.

Usually once you enable Steam input and re-order the controllers it should work fine, I also found that you sometimes have to restart Steam in Administrator Mode on Windows 10/11, otherwise you will run into some serious controller issues for a ton of games. But I just have Steam boot into Administrator Mode to bypass that problem.