real life stocks can't be easily/obviously manipulated like in the game,

I mean, sort of?

inconveniencing citizens, making them ill, killing indirectly, and finally killing directly all in the pursuit of making money in the stock market.

All those are possible, and happen. Look at what happened these last years, the money passing back and forth government and corporations, the censorship and lies, the effective outlawing of effective treatments, and the pushing of faulty treatments and practices. All that made the people at the top even more insanely wealthy. It's just slightly more roundabout than the simplified version in a video game.

I mean, Canada is killing citizens directly at this point, for at least in part financial gain.

EDIT: And if you want a bit more nebulous example, look at things like grain and oil subsidies (or paying farms not to produce other things), FDA food pyramids, over-prescription of drugs, and so much more; the government has been in/semi-directly killing its citizens for damn decades. They certainly profit off an unhealthy populace, and money passes back and forth between politicians and corporations nonstop, often to actively hurt the people.