For those who aren't familiar with it, FX recently announced a new direct-to-streaming series on Hulu, titled "Y: The Last Man". It's based on the 2000s-era Brian K. Vaughan-written Vertigo comic book of the same name, where an incident occurs that kills every mammal with a Y-chromosome on the planet - except for one dude named Yorick Brown, and his pet male capuchin monkey. With half the population instantly dead, you can imagine that chaos ensues, especially when you factor in that a good majority of infrastructure support jobs are handled by - you guessed it - men. (And that's not even taking into account the death of uncountable species across the world as they will no longer be able to procreate, the destruction of food supply, etc).
You can see the trailer here: https://www.youtube.com/watch?v=0EEQ5Lj-cXM
Obviously this series was written back before the huge push for inclusivity started, so its comic book iteration is not as horribly woke as it could be, but I'm just waiting for the shoe to drop on the TV version. Obviously, nature and genetics don't give two shits about your fee-fees and what you identify as, so that means if they go the full nine yards on this they're either going to have to:
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Ignore the existence of trans people entirely,
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Break the narrative and have it do something stupid like leave M-to-F trans alive but sterilize them,
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Downplay the whole event by claiming it killed "trans-women" as well, or
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Accept that M-to-F transgendered people genetically aren't women and lean into it and just show them as dead as well.
Somehow I think it's probably going to be option 2 or 3, but if it catches traction then the amount of salt this show is going to generate could season the world's popcorn for decades to come.
I'd expect them to gloss over it and ignore it before the event but then fill the cast with a whole bunch of FtM for after and do some handwaving for explanation/reasoning.
When they put themselves in that kind of corner, they will just go out of their way to not acknowledge it or get creative with angles and only show them leaning against one wall of that corner.