I don't want to get too into personal details, but I've worked with a lab that got into a "disagreement" with Eric Lander. I don't know if anyone else here has interacted more personally with him, but from my view point his work can be of variable quality, his papers deserve more questioning than they ever get, and listening to his talks he comes across as more of what I would call a "Celebrity scientist" who is interested in broad scale topics and big flashy papers/presentations, with not a lot of concern for details or substance.

I can't say I particularly trust the proposal or the man they have to guide it. I suppose that's par for the course with this administration however.