Two people with manual labor jobs could blow up an office building. A few more could take down a skyscraper. Five people in a Chinese virus lab disrupted global trade and killed many people.

I don't want to belie the complexity of the topic, but the potential for these things to happen is normally low. For instance, it's been possible to assassinate people by kamikaze ever since the advent of powered flight, even the most powerful people, but it's only happened a few times because of layers of social, professional, and informational constraints. As our culture falls apart, granted, some of those constraints will fall away as well.