Since you mentioned LTT I'll mention he's done this a few times over the years.
Here is a build he did with 7 GPUs that is basically a LAN party in a box.
A few years later he attempted to build a single PC that all his editors could use as an editing workstation
Apparently Unraid is designed to be able to do this sort of thing out of the box and uses KVM under the hood. Though personally I'm more familiar with esxi server, so that is what I use even if it's not quite as powerful (eg. you can't do software RAID with it).
Since you mentioned LTT I'll mention he's done this a few times over the years.
Here is a build he did with 7 GPUs that is basically a LAN party in a box.
A few years later he attempted to build a single PC that all his editors could use as an editing workstation
Apparently Unraid is designed to be able to do this sort of thing out of the box and uses KVM under the hood. Though personally I'm more familiar with esxi server, so that is what I use even if it's not quite as powerful (eg. you can't do software RAID with it).