I increasingly see that question on other forums and it drives me up the wall. That question is a perfect storm of two things: ▪︎the mindless consumer fanboy-ism that has destroyed all major film franchises ("it contradicts the lore, is objectively miserable, and an active waste of my time, but it has Star Trek in the title, so I'll watch it.") ▪︎developmentally stunted inability to fill in any blanks whatsoever
I promise you, Pee Pee Poo Poo: The Musical: Season 1 has absolutely no key nutrient you have to absorb to comprehend season 2. In fact, if we're talking one of these shows that go through three showrunners a season, it might be more comprehensible if you skip the earlier stuff.
Sometimes the sequel is completely different and deviates from the original show to follow the manga more closely. Think Hellsing vs Hellsing Ultimate.
Fullmetal Alchemist and Fullmetal Alchemist: Brotherhood is the same situation.