What on earth did they do to Isabela?

On the purely physical level, she apparently went from pirate queen to, what, Egyptian belly dancer (along with the obligatory bust size reduction)?

And, personality-wise? You're telling me that someone who is perpetually sarcastic, who Hawke first meets in a bar fight in DA2, who approves of Hawke getting every last coin possible out of people, who disapproves of sticking your nose in random people's business for no gain, and very nearly triggered a war among the three largest world powers by stealing the equivalent of the original copy of the Koran is now teaching people how to go through apology rituals for using the wrong pronouns?

Nuke it from orbit, several times. It's the only way to be sure.