By 'mainstream', I mean that Vtubers like in Japan would be on the morning talk shows, be featured in advertisements on TV, have shows about V-Tubers on TV (there is a light novel with an anime adaptation called VTuber Legend: How I Went Viral After Forgetting to Turn Off My Stream), collaborations with V-Tubers and sports teams are a common occurrence, and while we have had some of these things in the West, it's not as pervasive as it is in Japan.
In my opinion with Western media being continually ass, it's only a matter of time.
I thought Zen was a dude too until multiple streamers have talked about meeting Zen IRL, so I'm just gonna chalk it up to extra shyness, because it doesn't really matter.