Not really. Cassandra Nova has always been a female personality despite her mummudrai status as a psychic parasite of Professor X with all of his powers and potential powers because she copied his dna while still in the womb. The fact Xavier killed her before she was born didn't stop her because of the aforementioned dna fuckery of an extremely powerful psychic.

Instead this basically instilled an instinctive hatred, and/or fear of mutants depending which comics you read, which was why her very first appearance in the comics in the New X-Men series involved her mind controlling one of Bolivar Trask's relatives to the Wild Sentinel factory and then aiming it at Genosha, resulting in the deaths of around 16.5 million mutants in minutes. Even with such a high kill count of mutants Nova doesn't actually care about humans, she just wants to ruin Xavier any way she can out of revenge hence outing him as a mutant when possessing him on live TV, crashing the Shi'ar empire, and tormenting the X-Men however possible.

While this was done in part for establishing the danger that Nova posed the other reason for it was to return mutants to the status quo of being a small number of persecuted individuals rather than an entire nation, something stupidly happening again right now in the X-men comics with the fall of the island nation of Krakoa.

Other times such returns to the status quo have happened are M Day when Wanda reduced the mutant population to around 198 mutants after uttering "No more mutants" and rewriting reality to match. The problem is many readers are bored of this after having read it so many times now but Marvel doesn't take heed of the criticisms and instead keeps redoing previously popular stories that were only successful because it was something new.

Regardless of that, the point is that Cassandra Nova has always been female, extra planar psychic parasite status or not. Given modern Marvel it won't be a surprise this adaptation will ignore various concepts of the original character seeing as how quite a few later comics also did the same.

About the only good follow-up to Nova was the "What if?" that resulted in Nova joining with Emma Frost in an attempt to become the Phoenix because it ended with Emma/Nova literally having her heart pulled out of her chest by Kitty.

I wish they would take the Deadpool character seriously and do a real villain like Black Tom Cassidy. But that ship sailed after movie 1 I guess.