I don't play many PC games these days because of how woke a lot of the shit is. I got burned on Cyberpunk, so now I pretty much play FS2020 and that's it these days. The last game I played through was System Shock remake, which I found to be decent enough.
BG3 won game of the year from Worth a Buy, but I hear it has a lot of gay sex?
Do you have any specific quests in mind here which dont fit while you travel? It really arent that many epic quests really on the road. Only one which comes to my mind is the chest with beholder bottle in it. And that only really gives you an option to trade in the zentarim hideout. And the only tavern early on you find is burning. The Githranki on the road make sense because a giant ship crashed near by.
Cant really think of any major quests you cant pick up in npc hubs unless you count the Ravengard rescue from the burning tavern. Nightsong quest starts in the druid grove which is a big quest hub.