Season 3 episode 16 had the best argument for never putting children on hormones and the cluster effect of “kids being genderized”. The episode titled ‘Are you there God? It’s me, Jesus’ has an overlaying plot of Jesus being forced to do something spectacular for 2k. The very real subplot however was cartman shitting blood and thinking he had his period despite it being a virus going around. This lead to cartman starting a cult among the peer group to separate the “adults” from the “children”. Kenny also catching the virus was ecstatic to join the cult as an “adult”. Kyle end up lying about it to be allowed in. Stan, depressed his friends have singled him out as the only “child” goes on heavy hormones to induce puberty and get a period. The episode finalizes with god granting one question, to which Stan asked “why have I not gotten my period?” God replies (paraphrasing) that he was a boy and could not have periods, that the other boys mistook a virus for periods, and the other lies to fit in.