I'm just about through Scooby-doo Mystery Inc, and they lean a bit on Mayan/Aztec storylines -- what a wonderfully evocative era that seems to have absolutely no hold on mainstream culture! Were there any Manga artists that glommed onto it? Western would be cool too, unless it's about gay Mayans (etc)
As a side-note, French comics (Bande dessinee) had a bunch of wonderful south american stuff, but the one torrent that collected thousands of them seems to be dead.
The problem with portraying Mezoamericans in cartoons is you really have gloss over their tendency to carve the still-beating hearts out of people, including their own children.
Eh, Churchill starved millions of (dot) Indians to death, but I can still watch Sharpe's War.
Not Manga but...Emporers New Groove