Not even overruled. Advisory committee votes are not binding on any component of a drug application.
FDA can and has approved drugs that were unanimously voted against. These meetings used to have some value, but today FDA mostly convenes them as a way of building consensus and an appearance of having done their due diligence. What the committee says or how they vote won't change the outcome of a drug approval, which FDA frequently decides on prior to the meeting.
Not even overruled. Advisory committee votes are not binding on any component of a drug application.
FDA can and has approved drugs that were unanimously voted against. These meetings used to have some value, but today FDA mostly convenes them as a way of building consensus and an appearance of having done their due diligence. What the committee says or how they vote won't change the outcome of a drug approval, which FDA frequently decides on prior to the meeting.