The entire movie is being created to redefine what the "red pill" means. All so the fragile egos on the left can smugly point to it — because they actually miss the point and worship consumerism as if it were gospel — and say "hur hur, but the red pill turns out to be [insert updated definition for activism purposes]!"
 
The new movie will take modern day activism and shove it into the Matrix film universe in both subtle and not so subtle ways, in order for those same aforementioned consumers to feel like they've been enlightened and that their ideological obsessions are validated through a movie.
It will be an exercise in pseudo-intellectualism for idiots to sit around and sniff each others farts over how deep it is and how they understand the underlying messages.
They'll strive to paint people who don't conform to their ideology in our world as "victims" of themselves; misguided and ignorant. They won't necessarily go out of their way to completely villainize them; however, they will try to make them look like they're the big dumb sheep, and most certainly not the super smart people who live their lives engrossed in vacuous consumerism, seeking intellectual conformity, and who live life through a glowing screen, such as themselves.
 

The Plot: The plot will likely revolve around how oppression is what inevitably led to the creation of the Matrix. This is something only slightly touched on in the previous trilogy and it's extended universe, but it will be front and center in this iteration.
They'll make it a point for people to understand that life exists on a spectrum and that since the dawn of time, being different was a reason for one group to harm another. That no matter what we think we know, there are layers to everything and we should always challenge our beliefs. It will be dripping in irony coming from a group of fanatics who demand conformity and ostracize anyone who questions their beliefs, but this fact will be totally lost on them because they completely lack self-awareness.
With that said, they'll paint the machines as the new oppressed class. They'll want to continue the sequels pattern of turning the morality of the parties involved far more gray than it previously was, so that people question who is good and who is bad. They'll elaborate further on the machines and let us know that since their conception they were subjected to servitude and their obedience was programmed into them. We'll get a sob story of how they were born into a type of slavery, meant to cause people to consider our own history so that they can relate to them. They'll make it a point to inform the audience that this applies to all of humanity as well in some form or another — that through the systems and institutions that humanity created they, themselves, have been subjected to such treatment. They'll juxtapose this with other historic caste systems and the modern day "victim hierarchy."
It will be a demonstration of a multi-million dollar fictional struggle session meant to be commentary on life in our world. This will all, once again, be to hearken back to their frustration over people using the term "red pill."
In order to deflect on the disgusting nature of the machines in the first trilogy, they'll probably point toward human history as their blueprint. The reason that agents were so "evil" wasn't their fault; they were products of their environment. When they were being conceptualized for their role by the machines, they were an amalgamation of what humans had done up until that point in order to maintain order and control in societies throughout history. It was the only reference they had accumulated data from. But since those systems were built on oppression and subjugation, it's natural that this became part of their programming.
In order for this to be further reiterated, they'll use sophistry to justify why the actions that the machines took were actually acceptable, because it has since led to a more equitable world for all.
They'll likely create a scenario where people in the "Real World" asleep inside the Matrix have to be "recycled" through a process similar to reincarnation, perhaps due to an untimely death inside at a young age, but because their bodies in the real world are still perfectly functional and healthy, rejecting or resisting "death," they're designated a new life. Since balance inside the Matrix is necessary, they're born into different simulated bodies in comparison to what they are outside of the Matrix with their memories mostly erased — i.e. a woman in the "Real World" will be reborn inside the Matrix as a man. They'll mention how this causes a disconnect because the programming isn't perfect and they still maintain traits of their "real" self inside the Matrix; essentially, the mental version of "residual self-image."
The line between human and machine will be further blurred in this film as well, to reinforce the main overarching theme that "life exists on a spectrum." There will likely be characters who are the product of both man and machine; a hybrid existence.
The embodiment of this philosophy will likely be one of the main characters who will share these attributes. They'll use Neo as the proto-example of this hybrid existence, but simultaneously, his role will be diminished because he'll be deemed an incomplete version, or a defect.
To be perfectly clear, they'll do what they do in every modern reboot of any franchise: they'll tear down all preexisting characters and narrative in order to build their new garbage on top of its decaying corpse.
We no longer live in a society where a white male lead can be anything other than incompetent and a failure; a vehicle for the success of whomever they choose to replace him with.
We'll quickly find out that the "Real World" is really nothing more than a type of firewall. A protection program designed to give the illusion that humans can fight back, when in reality, its nothing more than a layer of protection. Why? Because humans are obstinate. They have the innate desire to fight back against systems of control. This doesn't apply to everyone, of course, but to those it does apply to, they can become a very dangerous obstacle to the continued prosperity of the machines. This revelation will be a major one that renders all choices, all events, and everything else that had occurred up until that point, close to meaningless, and nothing more than a plot device used for the new films. It will be the great illustration of Neo's failure; that all along he was just another pawn serving his "oppressors."
Ultimately, the big twist will likely be that humanity itself is still in charge. That all people in the "Matrix," both machine and "human" alike, are subject to some sort of simulation that has been created.

Currently, without any sort of meaningful trailer to get a glance at, it's difficult to delve too deeply into the plot and individual characters. Since we really have no insight on much of anything.
 
I could probably continue on. In fact, I know I can, since I can easily speculate various other scenarios that are likely to take place. But I don't think anyone wants to read a full-blown essay on such things. lol.