I think all of them pushed the vaxx fairly hard, unfortunately. I don't remember seeing how many of the unvaxxed pilots came back after the smoke cleared, if any.
My personal experience with them all is Southwest is the best for domestic, but as you already said they don't fly where you're going. For international flights,
I use United as they and their partners (specifically ANA airlines) haven't let me down before. I've never had a flight with American where my luggage didn't get lost, so if you're checking anything you may want to steer clear of them.
I haven't used Delta since the 90s so can't speak to them recently. Spirt just filed for bankruptcy. Haven't used Alaskan ever.
Haven't had the pleasure of my seat getting sold out from under me and I avoid San Fran so don't have to worry about scorpions lol.