The bit at 5:30 is basically emblematic of her blindness. She seems to disbelieve the idea that teenage boys are less likely to write letters their favorite mangaka.

If she had grown up male, Oda's words would immediately ring true, but she didn't and so she genuinely can't wrap her head around the idea. It's so bizarre to her that she says 'granted, this is Japan' and accepts that things might be different over there. No, woman. It's not 'Japan'.