I recently acquired Supernatural based on a few positive mentions here on KIA2. I quite like it, but it's a bit... off. These sorts of shows are really about the banter and camaraderie, with the monster stuff being almost incidental. Somehow the chemistry/banter is not quite working for me.
Should I persevere?
The only good thing about it is the chemistry between the brothers. It actually depicts a wholesome brotherly relationship, unlike most shows these days.
But I stopped watching at season 4 maybe. Without spoiling there's a point where they defeat the big bad... but then the show continues anyway?! If you keep watching you'll know when to stop.
That would be season 5.