Sounds like he's only describing the original sin scenario. The body recognises the virus is here 'again' and so makes the old but now innefective antibodies which just kinda interfers with recovery because they won't work, waste resources, and don't help you fight it, and the actual work of fighting it is delayed. You'd have been better off with a fresh exposure to it and actually learning to make all the antibodies that actually work to fight the whole thing.
Next step is full blown ADE, where they aren't just non-neutralising, but enhancing antibodies, the virus uses the antibodies to gain access to your cells, or they block neutralising antibodies and other mechanisms from fighting it. It's happened before with coronaviruses, its why trials never got very far before, infamously happened in a big trial in felines. Very high fatality. Like with dengue fever on your subsequent infections. It also happened with a big phase III dengue vaccine trial too. Nasty stuff.
You couldn't pay me to take the risk of this developing, and that's without the damage it does to your fertility.
Sounds like he's only describing the original sin scenario. The body recognises the virus is here 'again' and so makes the old but now innefective antibodies which just kinda interfers with recovery because they won't work, waste resources, and don't help you fight it, and the actual work of fighting it is delayed. You'd have been better off with a fresh exposure to it and actually learning to make all the antibodies that actually work to fight the whole thing.
Next step is full blown ADE, where they aren't just non-neutralising, but enhancing antibodies, the virus uses the antibodies to gain access to your cells, or they block neutralising antibodies and other mechanisms from fighting it. It's happened before with coronaviruses, its why trials never got very far before, infamously happened in a big trial in felines. Very high fatality. Like with dengue fever on your subsequent infections. It also happened with a big phase III dengue vaccine trial too. Nasty stuff.
You couldn't pay me to take the risk of this developing, and that's without the damage it does to your fertility.
The same process happens if you get infected by it in the past, and then get reinfrcged with the virus again months later. The immunity wanes.
And I am commie virus vaccine free.
Antigenic Original sin and ADE are not just waning immunity.