Video Game Outsiders, especially if you're listening in the car because they do a great job with their audio production and it overcomes road noise pretty well.

VGO is on a comedy network and so is equal part gaming podcast and comedy podcast. Michelle, one of the long-time co-hosts, proudly calls herself a troll, a shit-stirrer, and a member of the Glorious PC Master Race and gleefully skewers woke shit and games "made by people with blue hair." To the point that John, the other main host, will often cue up "God Save the Queen" as Michelle gets on her soapbox and rails against social justice shit ruining her enjoyment of games and humor.

Mix in John's manic antics (he may take some time to grow on you, as some episodes he can be kind of obnoxious and has a tendency to interrupt a LOT) and Matt, the token Canadian, taking flack for being high half the time he games and looking up "steam titty game" for their periodic NSFW episodes and you have a recipe for a gaming podcast that DGAF about who it offends and realizes that people need to lighten the fuck up and laugh.

It's the only podcast I pay money to subscribe to, which is also worth it because you get bonuses like Michelle's "Sane Gamer" episodes and the You Suck Show.

If you're looking for something more, Niche Gamer has a podcast that moved to Soundcloud and, IIRC, has never been the most frequent with updates. It was usually one several-hour episode per month. Good if you follow NG but doesn't have the punch of VGO.

Finally, there's Splash Damage with Scrivonaut and his wife Norayla, which focuses in specifically on politics where gaming and leftism converge. It's a little amateur, with Scrivonaut often fumbling for words, but I can say both hosts are sincere and any lack of eloquence on Scriv's part is more than made up for by insight.

VGO and SD are the ones I listen to most frequently, depending on whether I want politics or want to laugh at politics.