Speaking of OoT rando, it does have one "undroppable" quest item: Ruto's letter, taking up a bottle. It's not actually relevant in vanilla, being so close to where you turn it in, but it might be in rando, since you can theoretically find it without access to King Zora.

Even then, probably not all that relevant. I don't remember if you can get blue bottle off of it, but if you can, then that's 90% of the use of a bottle right there.

Speaking of OoT rando, it does have one "undroppable" quest item: Ruto's letter. It's not actually relevant in vanilla, being so close to where you turn it in, but it might be in rando, since you can theoretically find it without access to King Zora.

Even then, probably not all that relevant. I don't remember if you can get blue bottle off of it, but if you can, then that's 90% of the use of a bottle right there.